Ontologia genética
Função molecular	• acetylcholine receptor activator activity • kinase activity • cytoskeletal protein binding • ATP binding • protein kinase activity • protein serine/threonine kinase activity • ErbB-3 class receptor binding • transferase activity • ephrin receptor binding • tau-protein kinase activity • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • protein kinase binding • nucleotide binding • p53 binding • ErbB-2 class receptor binding • cyclin-dependent protein serine/threonine kinase activity • microtubule binding • tau protein binding • Hsp90 protein binding • voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Componente celular	• postsynaptic membrane • membrane • sinapse • citoesqueleto • cell projection • lamellipodium • soma • filopodium • growth cone • junção neuromuscular • membrana plasmática • axónio • neuronal cell body • GO:0097483, GO:0097481 postsynaptic density • junção celular • dendrito • protein kinase 5 complex • presynapse • cariolinfa • núcleo celular • citoplasma • citosol • microtúbulo • neuron projection • Schaffer collateral - CA1 synapse • postsynapse • glutamatergic synapse
Processo biológico	• synaptic transmission, glutamatergic • rhythmic process • negative regulation of cell cycle • oligodendrocyte differentiation • synaptic transmission, dopaminergic • protein phosphorylation • positive regulation of neuron apoptotic process • central nervous system neuron development • regulation of synaptic vesicle recycling • ciclo celular • regulated exocytosis • corpus callosum development • cell population proliferation • intracellular protein transport • neuron projection development • regulation of dendritic spine morphogenesis • negative regulation of synaptic plasticity • cerebellar cortex formation • exocitose • response to cocaine • GO:0097285 apoptose • regulation of apoptotic process • negative regulation of proteolysis • behavioral response to cocaine • synaptic vesicle exocytosis • receptor clustering • positive regulation of calcium ion-dependent exocytosis • telencephalon development • synaptic vesicle endocytosis • response to wounding • regulation of postsynaptic membrane potential • potencial pós-sináptico excitatório • Sinaptogênese • protein autophosphorylation • positive regulation of actin cytoskeleton reorganization • negative regulation of neuron death • chemical synaptic transmission • neuron apoptotic process • neuron projection morphogenesis • associative learning • dendrite morphogenesis • fosforilação • calcium ion import • Schwann cell development • neuron migration • cerebellum development • nervous system development • regulation of synaptic plasticity • diferenciação neural • cerebral cortex development • axon extension • nocicepção • positive regulation of protein binding • cell-matrix adhesion • peptidyl-threonine phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of axon extension • GO:0033109 cortical actin cytoskeleton organization • protein localization to synapse • positive regulation of protein targeting to membrane • positive regulation of protein kinase activity • visual learning • regulation of cell migration • axonogenesis • positive regulation of neuron death • receptor catabolic process • divisão celular • negative regulation of protein ubiquitination • positive regulation of signaling receptor activity • negative regulation of protein export from nucleus • layer formation in cerebral cortex • GO:0035404 peptidyl-serine phosphorylation • nucleocytoplasmic transport • cerebellar cortex development • forebrain development • motor neuron axon guidance • Migração celular • skeletal muscle tissue development • hippocampus development • regulation of macroautophagy • regulation of signal transduction by p53 class mediator • serine phosphorylation of STAT protein • microtubule cytoskeleton organization • positive regulation of protein phosphorylation • mitochondrion organization • positive regulation of glial cell apoptotic process • synaptic vesicle transport • regulation of synaptic transmission, glutamatergic • synapse pruning • positive regulation of presynaptic cytosolic calcium concentration • induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration • regulation of protein localization to plasma membrane • cellular response to amyloid-beta
Sources:Amigo / QuickGO

Padrão de expressão RNA

Mais dados de referência de expressão

Ortólogos

Espécie

Humano

Rato

Entrez


1020


n/a

Ensembl


ENSG00000164885


n/a

UniProt


Q00535


n/a

RefSeq (mRNA)


NM_001164410 NM_004935


n/a

RefSeq (proteína)


NP_001157882 NP_004926


n/a

Localização (UCSC)

n/a

Pesquisa PubMed

n/a

Wikidata

Ver/Editar Humano

A quinase 5 dependente de ciclina é uma proteína, e mais especificamente uma enzima, que é codificada pelo gene CDK5. A molécula pertence à família das quinases dependentes de ciclina. As quinases são enzimas que catalisam reações de fosforilação, processo que permite que o substrato ganhe um grupo fosfato doado por um composto orgânico conhecido como ATP. As fosforilações são de vital importância durante a glicólise, tornando as quinases uma parte essencial da célula devido ao seu papel no metabolismo, sinalização celular e muitos outros processos.

Estrutura

A Cdk5 é uma serina/treonina quinase dirigida por prolina, que foi identificada pela primeira vez como um membro da família CDK devido à sua estrutura semelhante à CDC2/CDK1 em humanos, uma proteína que desempenha um papel crucial na regulação do ciclo celular.

Doenças

Doenças associadas com CDK5 incluem Lisencefalia 7 Com Hipoplasia Cerebelar e Lisencefalia. Entre suas vias relacionadas estão o dano ao DNA e a resposta ao Ca2+ citosólico plaquetário elevado. Deficiência da proteína DJ-1 relacionada a Parkinson altera a sinalização de Cdk5 e induz a morte neuronal por reentrada aberrante do ciclo celular.

CDK5

Estrutura

Doenças

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